February 12, 2016Journal of Hypertension

cf-PWV was significantly increased in patients with Crohn's disease (mean difference 1.34 z-score; 95% CI 0.71-1.97 z-score; P < 0.0001) and ulcerative colitis (mean difference 1.08 z-score; 95% CI 0.55-1.61 z-score; P < 0.0001) compared to controls.

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Why the study?

Does inflammatory bowel disease increase arterial stiffness compared to controls, and does anti-TNFα therapy reduce it?

Population

1,011 participants from 9 cross-sectional studies, including 234 patients with Crohn's disease, 342 with…

Comparison

Inflammatory bowel disease; anti-TNFα therapy in… vs Control study participants

Design

Meta-analysis

Authors

LZLuca Zanoli SRStefania Rastelli AGAntonio Granata

Discussion

Member takes

Overview

Supports CV risk assessment in IBD; reinforces chronic inflammation's link to arterial stiffness.

Structured PICO

Does inflammatory bowel disease increase arterial stiffness compared to controls, and does anti-TNFα therapy reduce it?

Population

1,011 participants from 9 cross-sectional studies, including 234 patients with Crohn's disease, 342 with ulcerative colitis, and 435 control study participants.

Intervention

Inflammatory bowel disease (Crohn's disease or ulcerative colitis); anti-TNFα therapy in meta-regression

Comparator

Control study participants

Outcome

Carotid-femoral pulse wave velocity (cf-PWV)surrogate

Arterial stiffness, measured by cf-PWV, is significantly increased in patients with Crohn's disease and ulcerative colitis, and may be reduced by anti-TNFα therapy.

Cite This Study

Zanoli et al. (2016) studied this question.

synapsesocial.com/papers/6a7ec3cec95b32c6ab8ec173 https://doi.org/10.1097/hjh.0000000000000867

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February 12, 2016Journal of Hypertension

cf-PWV was significantly increased in patients with Crohn's disease (mean difference 1.34 z-score; 95% CI 0.71-1.97 z-score; P < 0.0001) and ulcerative colitis (mean difference 1.08 z-score; 95% CI 0.55-1.61 z-score; P < 0.0001) compared to controls.

View Full Paper

Ask AI

Bookmark

Why the study?

Does inflammatory bowel disease increase arterial stiffness compared to controls, and does anti-TNFα therapy reduce it?

Population

1,011 participants from 9 cross-sectional studies, including 234 patients with Crohn's disease, 342 with…

Comparison

Inflammatory bowel disease; anti-TNFα therapy in… vs Control study participants

Design

Meta-analysis

Authors

LZLuca Zanoli SRStefania Rastelli AGAntonio Granata

Discussion

Member takes

Overview

Supports CV risk assessment in IBD; reinforces chronic inflammation's link to arterial stiffness.

Structured PICO

Does inflammatory bowel disease increase arterial stiffness compared to controls, and does anti-TNFα therapy reduce it?

Population

1,011 participants from 9 cross-sectional studies, including 234 patients with Crohn's disease, 342 with ulcerative colitis, and 435 control study participants.

Intervention

Inflammatory bowel disease (Crohn's disease or ulcerative colitis); anti-TNFα therapy in meta-regression

Comparator

Control study participants

Outcome

Carotid-femoral pulse wave velocity (cf-PWV)surrogate

Arterial stiffness, measured by cf-PWV, is significantly increased in patients with Crohn's disease and ulcerative colitis, and may be reduced by anti-TNFα therapy.

Cite This Study

Zanoli et al. (2016) studied this question.

synapsesocial.com/papers/6a7ec3cec95b32c6ab8ec173 https://doi.org/10.1097/hjh.0000000000000867

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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