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June 4, 2014European Journal of Gastroenterology & Hepatology

Increased pulse wave velocity and relationship with inflammation, insulin, and insulin resistance in inflammatory bowel disease

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Key result

IBD is linked to higher pulse wave velocity, inflammatory markers, and insulin resistance versus controls.

  • P<0.05
  • n=176

Why the study?

Is inflammatory bowel disease associated with increased pulse wave velocity and insulin resistance independent of conventional cardiovascular risk factors?

Population

102 patients with inflammatory bowel disease without cardiovascular risk factors, evaluated in active and…

Design

Cohort

Authors

HKHüseyin Anıl KorkmazFŞFatih ŞahinSİSüleyman Hilmi İpekçi

Discussion

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Overview

May warrant closer CV surveillance in IBD; hypothesis-generating for inflammation-driven vascular risk beyond traditional factors.

Study Design

Type

Case-Control (n=176)

Structured PICO

Is inflammatory bowel disease associated with increased pulse wave velocity and insulin resistance independent of conventional cardiovascular risk factors?

P
Population
176 participants, comprising 102 patients with inflammatory bowel disease without cardiovascular risk factors and 74 matched controls.
C
Comparator
74 matched controls without IBD
O
Outcome
Pulse wave velocity (PWV) and biochemical parameters (ESR, CRP, insulin, HOMA-IR, homocysteine)surrogate

Main Result

p-value: p=<0.05

Inflammatory bowel disease is associated with increased arterial stiffness and inflammation-related factors independent of conventional cardiovascular risk factors.

Cite This Study

Korkmaz et al. (2014) conducted a case-control in Inflammatory bowel disease (n=176). Inflammatory bowel disease vs. Matched controls without inflammatory bowel disease was evaluated on 24 h, day and night pulse wave velocity (PWV) values, erythrocyte sedimentation rate, C-reactive protein, insulin, HOMA-IR, and homocysteine (p=<0.05). Inflammatory bowel disease was associated with higher pulse wave velocity, inflammatory markers, and insulin resistance compared to controls (P<0.05).

synapsesocial.com/papers/6aa92ca4669f42ee3902c53ahttps://doi.org/10.1097/meg.0000000000000104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arterial stiffness is increased in patients with inflammatory bowel disease2012 · 99 citations
  2. 2Arterial stiffness in inflammatory bowel disease2016 · 51 citations
  3. 3Inflammation and Aortic Pulse Wave Velocity: A Multicenter Longitudinal Study in Patients With Inflammatory Bowel Disease2019 · 72 citations
  4. 4Arterial Stiffness in Inflammatory Bowel Disease: An Updated Systematic Review and Meta-Analysis2021 · 9 citations
  5. 5Increased arterial stiffness – similar findings in patients with inflammatory bowel disease without prior hypertension or diabetes and in patients with well-controlled hypertension2018 · 17 citations