Key result
Inflammatory bowel disease was associated with significantly increased arterial stiffness, measured by carotid-femoral pulse wave velocity, compared to controls (MD 0.70; 95% CI 0.48-0.92; P<.01).
Why the study?
The study was conducted to explore whether arterial stiffness is associated with inflammatory bowel disease.
Is inflammatory bowel disease associated with increased arterial stiffness compared to controls?
Population
2188 participants across 17 eligible trials including 558 with UC and 693 with CD
Comparison
Patients with IBD (UC and CD) vs control groups
Design
Systematic review and meta-analysis
Authors
Loading...
May warrant CV risk assessment in IBD; extends observational evidence on vascular involvement without proving causality.
Meta-Analysis (n=2,188)
Is inflammatory bowel disease associated with increased arterial stiffness compared to controls?
Mean Difference: 0.7 (95% CI 0.48–0.92)
p-value: p=<.01
Inflammatory bowel disease, including both ulcerative colitis and Crohn's disease, is associated with significantly increased arterial stiffness.
Lu et al. (2021) conducted a meta-analysis in Inflammatory bowel disease (IBD) (n=2,188). Inflammatory bowel disease vs. Control groups was evaluated on Carotid-femoral pulse wave velocity (CPWV) (MD 0.70, 95% CI 0.48-0.92, p=<.01). Inflammatory bowel disease was associated with significantly increased arterial stiffness, measured by carotid-femoral pulse wave velocity, compared to controls (MD 0.70; 95% CI 0.48-0.92; P<.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: