Key result
Inflammatory bowel disease is linked to ~1.3 m/s higher carotid-femoral pulse wave velocity.
Why the study?
Do patients with normotensive, normoglycemic inflammatory bowel disease without traditional cardiovascular risk factors have increased subclinical atherosclerosis and endothelial dysfunction (measured by cf-PWV, FMD, and CIMT) compared with matched healthy controls?
Cross-Sectional (n=192)
Assessor-blinded (specialists measuring PWV, IMT, and FMD were blind to participants' clinical characteristics)
No
Do patients with normotensive, normoglycemic inflammatory bowel disease without traditional cardiovascular risk factors have increased subclinical atherosclerosis and endothelial dysfunction (measured by cf-PWV, FMD, and CIMT) compared with matched healthy controls?
Answers are grounded in this paper and cite their sources.
Patients with inflammatory bowel disease free of traditional cardiovascular risk factors exhibit increased arterial stiffness (cf-PWV) and impaired endothelial function (FMD) compared with healthy controls, with arterial stiffness correlating independently with disease duration.
BACKGROUND: Patients with inflammatory bowel disease (IBD) have increased risk for atherosclerosis. The cause of increased cardiovascular risk is not fully understood. Chronic inflammatory process may predispose to atherosclerosis. We aimed primarily to investigate subclinical atherosclerosis in patients with IBD, by measuring carotid femoral pulse wave velocity (PWV), carotid intima media thickness, and flow-mediated dilatation compared with matched normal controls. METHODS: Patients with IBD were recruited among individuals proven to have Crohn's disease (CD) and ulcerative colitis (UC). To exclude any interference of confounding factors for endothelial dysfunction or atherosclerosis, we studied a specifically selected group with no additional cardiovascular risk. PWV, carotid intima media thickness, and flow-mediated dilatation levels were measured in all patients and controls. RESULTS: The carotid femoral PWV levels were 8.13 ± 1.61 m/sec in the patients with UC, 8.16 ± 1.74 m/sec in the patients with CD, and 6.85 ± 0.95 m/sec in the healthy subjects. The levels of carotid femoral PWV were significantly higher in patients with CD and UC than control group (P < 0.001). Flow-mediated dilatation levels were significantly decreased in patients with UC and CD (9.6% ± 5.1% versus 108% ± 4.4%) when compared with control subjects (15.1% ± 9.7%) (P = 0.004). No significant difference in carotid intima media thickness was detected between UC, CD, and control groups (P = 0.152). CONCLUSIONS: This study suggests that patients with IBD without traditional cardiovascular risk factors have increased risk of endothelial dysfunction and atherosclerosis.
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Öztürk et al. (2015) conducted a cross-sectional in Inflammatory bowel disease (Crohn's disease and ulcerative colitis) without traditional cardiovascular risk factors (n=192). Inflammatory bowel disease (ulcerative colitis and Crohn's disease) vs. Healthy control subjects matched for age, gender, and smoking without risk factors of atherosclerosis was evaluated on Carotid femoral pulse wave velocity (cf-PWV, m/sec) (p=<0.001). Inflammatory bowel disease was associated with higher carotid-femoral pulse wave velocity (8.13 m/s in UC, 8.16 m/s in CD vs 6.85 m/s in controls; P<0.001) and lower FMD (P=0.004).
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