Key result
Pediatric IBD linked to ~8% higher carotid pulse wave velocity, indicating increased arterial stiffness.
Why the study?
Patients with inflammatory bowel disease have a higher incidence of CVD, making early diagnosis of arterial damage essential to prevent future vascular risk.
Does pediatric inflammatory bowel disease increase arterial stiffness and subclinical atherosclerosis compared to healthy controls?
Case-Control (n=50)
No
Does pediatric inflammatory bowel disease increase arterial stiffness and subclinical atherosclerosis compared to healthy controls?
Carotid pulse wave velocity is significantly elevated in children with IBD, suggesting it may be an effective and easy method to detect early subclinical atherosclerosis in this population.
Answers are grounded in this paper and cite their sources.
May signal early vascular changes warranting surveillance in pediatric IBD; extends prior associations but leaves open clinical utility pending prospective data.
Objective: Patients with inflammatory bowel disease (IBD) have a higher incidence of cardiovascular disease (CVD). Early diagnosis of arterial damage is essential to prevent future vascular risk. We aimed to assess the vascular involvement IBD by monitoring inflammation parameters, echocardiography, augmentation index (AIx); carotid pulse wave velocity (PWV), carotid intima-media thickness (cIMT), and blood pressure. Method: The patient population included 25 subjects with a previously biopsy-proven diagnosis of IBD who had been on treatment for at least one year. Carotid PWV, AIx, and cIMT of the patients were measured. Results: Twenty-five patients (15 female and 10 male) with IBD and 25 healthy controls were included in this present study. There was a significant difference between the carotid PWV values (mean 4.84±0.39, 4.49±0.17, respectively, p <0.001), but no differences were observed in the cIMT and AIx values. Conclusion: The carotid PWV values assessing arterial stiffness may be effective, safe, and easy to detect subclinical atherosclerosis in children with IBD. Larger studies should be carried out to evaluate other indicators of early atherosclerosis and arterial stiffness such as cIMT and AIx.
No takes yet. Share an insight, caveat, or question.
Taşçı et al. (2023) conducted a case-control in Pediatric inflammatory bowel disease (n=50). Inflammatory bowel disease vs. Healthy controls was evaluated on Carotid pulse wave velocity (PWV) (p=<0.001). Pediatric patients with inflammatory bowel disease had significantly higher carotid pulse wave velocity compared to healthy controls (4.84 vs 4.49 m/s, p<0.001), indicating increased arterial stiffness.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: