Key result
Inflammatory bowel disease is linked to ~88% greater epicardial adipose tissue thickness vs controls.
Why the study?
Early atherosclerosis detection methods in inflammatory bowel disease patients without traditional cardiovascular risk factors were needed to improve diagnosis.
Does inflammatory bowel disease increase epicardial adipose tissue and carotid intima media thickness in patients without traditional cardiovascular risk factors?
Case-Control (n=72)
Single-blind
Does inflammatory bowel disease increase epicardial adipose tissue and carotid intima media thickness in patients without traditional cardiovascular risk factors?
Absolute Event Rate: 0.448% vs 0.238%
p-value: p=<0.001
Epicardial adipose tissue and carotid intima media thickness are significantly increased in IBD patients without traditional cardiovascular risk factors, suggesting their utility in detecting early subclinical atherosclerosis.
EAT thickness may flag subclinical atherosclerosis in IBD without conventional risks; hypothesis-generating and should not yet change practice.
The aim of this study was to detect early atherosclerosis in patients with inflammatory bowel disease (IBD) that were strictly selected according to traditional cardiovascular risk factors, and to demonstrate whether evaluating epicardial adipose tissue can serve as an imaging modality through which to detect early atherosclerosis. Forty-three patients with IBD and 29 controls were enrolled in the study. Participants with well-known cardiovascular risk factors were excluded. Carotid intima media thickness (CIMT) and epicardial adipose tissue (EAT) were evaluated by the same physician blinded to the study groups. CIMT and EAT values were significantly higher in the IBD group when compared to the control group (p<0.01 and p<0.001, respectively). EAT was correlated with CIMT in the IBD group (r=0.574, p=0.001). CIMT and EAT are functional imaging methods that are used to detect early atherosclerosis in IBD patients without classic cardiovascular risk factors. EAT may be used as an additional diagnostic tool through which to detect early atherosclerosis in clinical practice in IBD patients.
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Gözel et al. (2019) conducted a case-control in Inflammatory bowel disease (n=72). Inflammatory bowel disease vs. Healthy controls was evaluated on Epicardial adipose tissue (EAT) thickness in cm (p=<0.001). Patients with inflammatory bowel disease without traditional cardiovascular risk factors had significantly higher epicardial adipose tissue thickness (0.448 cm vs 0.238 cm, p<0.001) compared to healthy controls.
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