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All articles of this category We have developed the first synthesis of N , N -disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution of 5-bromothiophene-2-carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to the corresponding imines or amino derivatives respectively. aminothiophenes - nucleophilic aromatic substitution - aqueous solution
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Prim et al. (1998) studied this question.
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