One hundred years after the first isolation of natural (R)-muscone [(R)-1], a short and efficient access to the outstanding odorants (R)-1 and (R,Z)-5-muscenone [(R)-2] has become possible thanks to an unprecedented, reversible intramolecular aldol addition/enantioselective dehydration (up to 76 % ee; see scheme).
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Knopff et al. (2007) studied this question.
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