Population
Cultured 1.17 cells (immortalized rat sciatic nerve Schwann cell line)
Comparison
Inhibition of LPL activity using… vs Untreated cells or cells treated with preimmune…
Design
Preclinical
Follow-up
up to 24 h
Authors
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LPL supports fatty acid supply for Schwann cell lipids; leaves open its necessity for myelin biosynthesis in vivo.
LPL is expressed in Schwann cells and its mediated hydrolysis of exogenous triacylglycerol is an important source of free fatty acids, potentially playing a critical role in myelin biosynthesis.
Huey et al. (1998) studied this question.
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