Key result
Pancuronium produced a profound vagolytic response under urethane anaesthesia, whereas cisatracurium produced no evidence of vagolytic action under either urethane or isoflurane anaesthesia.
Why the study?
Does the choice of neuromuscular blocker (pancuronium vs cisatracurium) affect vagal control of heart rate in Lewis rats under different anaesthetics?
Does the choice of neuromuscular blocker (pancuronium vs cisatracurium) affect vagal control of heart rate in Lewis rats under different anaesthetics?
In laboratory animal research, cisatracurium is preferable to pancuronium for neuromuscular blockade when examining autonomic function, as it avoids vagolytic effects.
Answers are grounded in this paper and cite their sources.
Positions cisatracurium as the preferred neuromuscular blocker for preserving autonomic function in preclinical models; leaves.
Neuromuscular-blocking agents are commonly used in laboratory animal research settings. Due to actions of cholinergic receptors at locations other than the motor end-plate, these agents have a strong propensity to modulate autonomic outflow and may therefore not be desirable in studies examining autonomic function. This study aimed to compare the effect of two non-depolarizing neuromuscular-blocking agents, pancuronium and cisatracurium, on blood pressure, heart rate and non-invasive indices of autonomic function (heart rate variability, systolic blood pressure variability and baroreflex sensitivity) under two different types of anaesthesia in Lewis rats. Pancuronium produced a profound vagolytic response characterized by tachycardia, reduction in heart rate variability and baroreflex sensitivity under urethane anaesthesia, and with minimal effect under isoflurane anaesthesia. Conversely, cisatracurium produced no evidence of vagolytic action under either urethane or isoflurane anaesthesia. Therefore, for studies interested in examining autonomic function, particularly baroreflex or vagal function, neuromuscular blockade would be best achieved using cisatracurium.
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Kandukuri et al. (2017) studied Laboratory animal experimental conditions. Pancuronium vs. Cisatracurium was evaluated on Blood pressure, heart rate and non-invasive indices of autonomic function (heart rate variability, systolic blood pressure variability and baroreflex sensitivity). Pancuronium produced a profound vagolytic response under urethane anaesthesia, whereas cisatracurium produced no evidence of vagolytic action under either urethane or isoflurane anaesthesia.
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