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March 21, 2007European Journal of Anaesthesiology

Dynamics of neuronal assemblies are modulated by anaesthetics but not analgesics

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Key result

Sevoflurane and propofol anaesthesia suppressed heart rate variability, and deeper surgical levels reduced the complexity of heart rate variability.

Why the study?

Do surgical levels of propofol and sevoflurane anaesthesia alter heart rate dynamics and variability in healthy male subjects?

Population

24 healthy male subjects

Comparison

Sevoflurane or propofol anaesthesia targeted to… vs Comparison between different anaesthetic…

Design

Other

Authors

TCToby F.T. CollinsEMEdward O. MannMHMichael Hill

Discussion

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Overview

May confound HRV-guided monitoring under anaesthesia; leaves open effects on perioperative outcomes in patients.

Structured PICO

Do surgical levels of propofol and sevoflurane anaesthesia alter heart rate dynamics and variability in healthy male subjects?

P
Population
24 healthy male subjects undergoing sevoflurane or propofol anaesthesia.
I
Intervention
Sevoflurane or propofol anaesthesia targeted to match 1.0, 1.5 and 2.0 minimal alveolar concentration/effective concentration 50, and regimens targeted to bispectral index 40 (sevoflurane alone, sevoflurane + 70% nitrous oxide, propofol alone, propofol + 70% nitrous oxide)
C
Comparator
Comparison between different anaesthetic regimens (sevoflurane vs. propofol, with or without nitrous oxide) and baseline
O
Outcome
Heart rate dynamics/variability measured using conventional time and frequency domain methods, and approximate entropysurrogate

Surgical levels of sevoflurane and propofol anaesthesia significantly suppress heart rate variability and reduce its complexity in healthy subjects.

Cite This Study

Collins et al. (2007) studied Healthy subjects (n=24). Sevoflurane and propofol vs. Each other / baseline was evaluated on Heart rate variability and approximate entropy. Sevoflurane and propofol anaesthesia suppressed heart rate variability, and deeper surgical levels reduced the complexity of heart rate variability.

synapsesocial.com/papers/6a84734974ee596ff2c52620https://doi.org/10.1017/s026502150700004x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Effects of Propofol and Sevoflurane on Heart Rate Variability2003 · 294 citations
  2. 2Neuroendocrine Stress Response and Heart Rate Variability: A Comparison of Total Intravenous Versus Balanced Anesthesia2005 · 162 citations
  3. 3The effects of surgical levels of sevoflurane and propofol anaesthesia on heart rate variability2007 · 40 citations
  4. 4Effect of cardiac vagal outflow on complexity and fractal correlation properties of heart rate dynamics2003 · 83 citations
  5. 5Altered Complexity and Correlation Properties of R-R Interval Dynamics Before the Spontaneous Onset of Paroxysmal Atrial Fibrillation1999 · 251 citations