Key result
Induction with 8% Sevoflurane caused a significantly greater reduction in heart rate post-induction compared to 1% Propofol, which caused a greater transient decrease in mean arterial pressure (P<0.05).
Why the study?
Does intravenous 1% Propofol compared to inhalation of 8% Sevoflurane affect mean arterial pressure and heart rate during induction of anesthesia in ASA physical status I patients?
RCT (n=108)
randomized
Does intravenous 1% Propofol compared to inhalation of 8% Sevoflurane affect mean arterial pressure and heart rate during induction of anesthesia in ASA physical status I patients?
p-value: p=<0.05
Propofol induction causes a greater transient decrease in mean arterial pressure, whereas sevoflurane induction causes a greater reduction in heart rate in healthy patients undergoing elective surgery.
Alerts to differing hemodynamic responses; leaves open optimal agent selection pending higher-level evidence.
Background: Induction of anesthesia is a critical event and hemodynamic stability is an important factor during this period. Propofol is a commonly used intravenous anesthetic and Sevoflurane is a newly introduced inhalational anesthetic in the context of a developing country. This study compared the hemodynamics on induction of anesthesia with Propofol and Sevoflurane.Methods: A total of 108 American Society of Anesthesiologists physical status I patients undergoing elective surgical procedures under general anesthesia were randomized into two groups. Group ‘P’ patients were induced with intravenous 1% Propofol and Group ‘S’ patients were induced with inhalation of 8% Sevoflurane. Mean arterial pressures and heart rates were recorded at baseline, before induction, during induction and at 1, 3 and 5 minutes after induction of anesthesia before endotracheal intubation.Results: The two groups were comparable with respect to demographics and baseline hemodynamic parameters. There was a significant decrease in mean arterial pressure and heart rate from pre-induction values within both groups during and after induction. The reduction in mean arterial pressure was significantly more in Propofol group transiently during induction. The reduction in heart rate was significantly more in Sevoflurane group at 1, 3 and 5 minutes after induction (P < 0.05).Conclusion: Induction of anesthesia with Propofol demonstrated a greater decrease in mean arterial pressure whereas induction with Sevoflurane was associated with greater reduction in heart rate.
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Rawal et al. (2015) conducted an RCT in Elective surgical procedures under general anesthesia (n=108). Sevoflurane vs. Propofol 1% was evaluated on Mean arterial pressure and heart rate (p=<0.05). Induction with 8% Sevoflurane caused a significantly greater reduction in heart rate post-induction compared to 1% Propofol, which caused a greater transient decrease in mean arterial pressure (P<0.05).
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