Key result
Vital capacity induction with 8% sevoflurane resulted in a significantly faster induction time compared to intravenous propofol (53.33 vs 72.27 seconds; p=0.01).
Why the study?
Intravenous propofol is standard for induction of general anesthesia, but sevoflurane also produces rapid induction, prompting a comparison of induction time and quality between the two agents.
Does sevoflurane 8% via vital capacity induction reduce induction time compared to intravenous propofol 1% in patients undergoing elective laparoscopic surgery?
Population
102 patients undergoing elective laparoscopic surgery
Comparison
Sevoflurane 8% via vital capacity induction vs intravenous propofol 1%
Authors
Loading...
Sevoflurane vital capacity induction may provide rapid, lower-cost alternative to propofol; leaves open need for confirmatory RCTs before practice change.
RCT (n=102)
Does sevoflurane 8% via vital capacity induction reduce induction time compared to intravenous propofol 1% in patients undergoing elective laparoscopic surgery?
Absolute Event Rate: 53.33% vs 72.27%
p-value: p=0.01
Vital capacity induction with 8% sevoflurane provides faster and cheaper induction compared to intravenous propofol, with comparable hemodynamic stability.
Adhikari et al. (2020) conducted an RCT in Elective laparoscopic surgery (n=102). Sevoflurane via vital capacity induction vs. Intravenous propofol 1% with titrating dose was evaluated on Induction time (p=0.01). Vital capacity induction with 8% sevoflurane resulted in a significantly faster induction time compared to intravenous propofol (53.33 vs 72.27 seconds; p=0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: