Why the study?
Does propofol infusion alter baroreceptor reflex regulation of cardiac rate and sympathetic nerve activity in healthy volunteers?
Population
7 healthy, normotensive, young (19-26 yr), male volunteers.
Comparison
Continuous infusions of propofol under… vs Conscious state (awake values).
Design
Other
Follow-up
Acute (during infusion)
Authors
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May warrant caution with propofol amid hypotension; leaves open effects on perioperative outcomes.
Does propofol infusion alter baroreceptor reflex regulation of cardiac rate and sympathetic nerve activity in healthy volunteers?
Propofol markedly attenuates reflex responses to hypotension, but these reflex sympathetic responses are better maintained in hypercarbic conditions and when lower doses are used with nitrous oxide.
Ebert et al. (1994) studied this question.
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