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December 1, 1989DICP

Severe Cardiovascular Adverse Effects in Association with Acute, High-Dose Corticosteroid Administration

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Why the study?

Does high-dose intravenous corticosteroid therapy cause severe cardiovascular adverse reactions in patients?

Population

Patients receiving high-dose intravenous corticosteroid therapy, most having underlying renal disease and/or…

Design

Review

Authors

BEBrian L. ErstadUniversity of Arizona

Discussion

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Implication

Supports monitoring for cardiovascular events with high-dose IV corticosteroids; leaves open causality and requires controlled trials.

Structured PICO

Does high-dose intravenous corticosteroid therapy cause severe cardiovascular adverse reactions in patients?

P
Population
Patients receiving high-dose intravenous corticosteroid therapy, most having underlying renal disease and/or undergoing renal transplantation.
I
Intervention
High-dose intravenous corticosteroid therapy (at least 250 mg of methylprednisolone or equivalent, usually administered over a 30-minute period or less).
O
Outcome
Severe cardiovascular adverse reactions including death, arrhythmias, and myocardial infarctions.safety

Caution is advised when administering high-dose intravenous corticosteroids due to potential severe cardiovascular adverse reactions.

Limitations

  • Lack of controlled trials to prove cause-effect relationship

Cite This Study

Brian L. Erstad (1989) studied this question.

synapsesocial.com/papers/6a84743c121b098de683f0bdhttps://doi.org/10.1177/106002808902301215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fatal Arrhythmia After Pulse Methylprednisolone Therapy1981 · 86 citations
  2. 2A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock1987 · 1,450 citations
  3. 3EFFECTS OF HIGH-DOSE INTRAVENOUS METHYLPREDNISOLONE ON CIRCULATION IN HUMANS1983 · 27 citations
  4. 4Cortisone and Blood Pressure.1951 · 27 citations
  5. 5Effects of a single large intravenous dose of methylprednisolone sodium succinate1970 · 102 citations