Key result
Deteriorating glucose metabolism status and extending diabetes duration were associated with an initial increase and subsequent regression of negative default mode network connectivity.
Why the study?
Diabetes increases the risk for cognitive impairment, but the precise mechanisms and changes in default mode network connectivity across different glucose metabolism statuses and diabetes durations remain poorly understood.
Does default mode network connectivity change across different stages of glucose metabolism impairment and diabetes duration?
Cross-Sectional (n=145)
Does default mode network connectivity change across different stages of glucose metabolism impairment and diabetes duration?
Default mode network connectivity exhibits distinct, non-linear patterns across the spectrum of glucose impairment and diabetes duration, suggesting early neuroimaging markers for diabetic brain damage.
AIMS/HYPOTHESES: It is now generally accepted that diabetes increases the risk for cognitive impairment, but the precise mechanisms are poorly understood. In recent years, resting-state functional magnetic resonance imaging (rs-fMRI) is increasingly used to investigate the neural basis of cognitive dysfunction in type 2 diabetes (T2D) patients. Alterations in brain functional connectivity may underlie diabetes-related cognitive dysfunction and brain damage. The aim of this study was to investigate the changes in default mode network (DMN) connectivity in different glucose metabolism status and diabetes duration. METHODS: We used a seed-based fMRI analysis to investigate positive and negative DMN connectivity in four groups (39 subjects with normal glucose metabolism [NGM], 23 subjects with impaired glucose metabolism [IGM; i.e., prediabetes], 59 T2D patients with a diabetes duration of <10 years, and 24 T2D patients with a diabetes duration of ≥10 years). RESULTS: Negative DMN connectivity increased and then regressed with deteriorating glucose metabolism status and extending diabetes duration. DMN connectivity showed a significant correlation with diabetes duration. CONCLUSION/INTERPRETATION: This study suggests that DMN connectivity may exhibit distinct patterns in different glucose metabolism status and diabetes duration, providing some potential neuroimaging evidence for early diagnosis and further understanding of the pathophysiological mechanisms of diabetic brain damage.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2018) conducted a cross-sectional in Type 2 diabetes and impaired glucose metabolism (n=145). Deteriorating glucose metabolism and diabetes duration vs. Normal glucose metabolism was evaluated on Changes in default mode network (DMN) connectivity. Deteriorating glucose metabolism status and extending diabetes duration were associated with an initial increase and subsequent regression of negative default mode network connectivity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: