Why the study?
What is the mechanism of flush induced by nicotinic acid in guinea-pigs?
Population
Guinea-pigs (in vivo ears and isolated ear slices)
Design
Preclinical
Authors
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Prostaglandin mediation of nicotinic acid flush shown in guinea pigs; leaves open human relevance and requires clinical confirmation.
What is the mechanism of flush induced by nicotinic acid in guinea-pigs?
Nicotinic acid-induced flush appears to be mediated by prostaglandin synthesis, which subsequently increases cyclic AMP levels.
Andersson et al. (1977) studied this question.
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