What question did this study set out to answer?

To determine the electrophysiological effects of 5-hydroxytryptamine, dopamine, and noradrenaline on enteric neurones within the submucous plexus of the small intestine.

October 1, 1975The Journal of PhysiologyOpen Access

Some effects of 5‐hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea‐pig small intestine.

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To determine the electrophysiological effects of 5-hydroxytryptamine, dopamine, and noradrenaline on enteric neurones within the submucous plexus of the small intestine.
Applied 5-hydroxytryptamine (5-HT), dopamine, and noradrenaline via iontophoresis to submucous plexus neurones isolated from guinea-pig small intestine.
Recorded changes in membrane potential and tested the susceptibility of catecholamine responses and transmural stimulation-evoked inhibitory synaptic potentials to methysergide antagonism.
5-HT elicited excitatory responses in 100% of tested submucous plexus neurones.
Dopamine and noradrenaline increased membrane potential specifically in the subset of neurones that received inhibitory innervation, replicating the profile of inhibitory synaptic potentials.
Methysergide blocked both the hyperpolarizing responses to dopamine and noradrenaline and the electrically evoked inhibitory synaptic potentials.

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Implication

Electrophysiological study reveals that 5-HT excites while catecholamines inhibit guinea-pig submucous neurones, indicating shared receptor pathways for synaptic inhibition.

Cite This Study

Hirst et al. (1975) studied this question.

synapsesocial.com/papers/6a8477c13b499be099c6be71 https://doi.org/10.1113/jphysiol.1975.sp011124

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Implication

Electrophysiological study reveals that 5-HT excites while catecholamines inhibit guinea-pig submucous neurones, indicating shared receptor pathways for synaptic inhibition.

Some effects of 5‐hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea‐pig small intestine.

Key Points

Discussion

Implication

Cite This Study

Some effects of 5‐hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea‐pig small intestine.

Key Points

Discussion

Implication

Cite This Study

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