Key result
Tumor cells from a boy with cellular immunodeficiency and endobronchial leiomyoma were positive for Epstein-Barr virus markers, suggesting a role for the virus in leiomyoma pathogenesis.
Case Report (n=1)
This case suggests a potential role of Epstein-Barr virus in the pathogenesis of bronchial leiomyoma in immunocompromised children.
Supports possible EBV role in rare pediatric endobronchial leiomyoma; hypothesis-generating and should not change practice.
Bronchial leiomyoma is a rare disease in children. Recently, the association of leiomyoma and HIV infection was reported. We describe a boy with a cellular immunodeficiency, who had endobronchial leiomyoma. The tumor cells were positive for Epstein-Barr virus-encoded RNA-1 (EBER-1) and Epstein-Barr virus-determined nuclear antigen-2, suggesting a role of Epstein-Barr virus in the pathogenesis of leiomyoma.
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Hatano et al. (2006) conducted a case report in Bronchial leiomyoma and cellular immunodeficiency (n=1). Epstein-Barr virus infection was evaluated on Tumor cell positivity for EBER-1 and EBNA-2. Tumor cells from a boy with cellular immunodeficiency and endobronchial leiomyoma were positive for Epstein-Barr virus markers, suggesting a role for the virus in leiomyoma pathogenesis.
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