Population
In vitro motility assay using actin filaments from smooth and skeletal muscle
Comparison
Smooth muscle actin filaments vs Skeletal muscle actin filaments
Design
Preclinical
Authors
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In vitro actin equivalence shifts focus to myosin isoforms; leaves open in vivo validation before any mechanistic or therapeutic inferences.
Smooth and skeletal muscle actin isoforms are mechanically indistinguishable in vitro, suggesting smooth muscle's enhanced force generation originates within its specific myosin molecule.
Harris et al. (1993) studied this question.
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