Key result
High Gal-3 serum levels were associated with 1-year worsening of renal function in chronic heart failure outpatients (OR 1.09; 95% CI 1.03-1.15; p=0.004).
Why the study?
The study was conducted to evaluate the association between Gal-3 serum levels and the progression of renal dysfunction in chronic heart failure outpatients.
Are Gal-3 serum levels associated with worsening of renal function in chronic heart failure outpatients?
Cohort (n=260)
Are Gal-3 serum levels associated with worsening of renal function in chronic heart failure outpatients?
Odds Ratio: 1.09 (95% CI 1.03–1.15)
p-value: p=0.004
Gal-3 serum levels may serve as a useful biomarker for predicting the progression of cardiorenal syndrome in chronic heart failure outpatients.
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May inform renal monitoring in chronic HF outpatients; hypothesis-generating and requires prospective validation before practice change.
Iacoviello et al. (2019) conducted a cohort in chronic heart failure (n=260). High Gal-3 serum levels was evaluated on 1-year worsening of renal function (OR 1.09, 95% CI 1.03-1.15, p=0.004). High Gal-3 serum levels were associated with 1-year worsening of renal function in chronic heart failure outpatients (OR 1.09; 95% CI 1.03-1.15; p=0.004).
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