Novel renal biomarkers such as cystatin C, KIM-1, NGAL, and FABP provide important prognostic information and may detect acute changes in renal function earlier than serum creatinine in patients with heart failure.
Renal function is the most important predictor of clinical outcome in heart failure (HF). It is therefore essential to have accurate and reliable measurement of renal function and early specific markers of renal impairment in patients with HF. Several renal functional entities exist, including glomerular filtration (GFR), glomerular permeability, tubulointerstitial damage, and endocrine function. Different markers have been studied that can be used to determine changes and the effect of treatment in these entities. In the present review, we summarize current and novel markers that give an assessment of renal function and prognosis in the setting of acute and chronic HF.
Damman et al. (Sat,) conducted a review in Heart failure. Renal biomarkers was evaluated. Novel renal biomarkers such as cystatin C, KIM-1, NGAL, and FABP provide important prognostic information and may detect acute changes in renal function earlier than serum creatinine in patients with heart failure.