Key result
In a meta-analysis of 529 patients, perioperative levosimendan therapy decreased the postoperative incidence of acute kidney injury compared to control in adults undergoing cardiac surgery.
Why the study?
Does perioperative levosimendan reduce the incidence of acute kidney injury in adult patients undergoing cardiac surgery?
Population
529 adult patients undergoing cardiac surgery (pooled from 5 randomized trials)
Comparison
Perioperative levosimendan vs Placebo or any other control
Design
Meta-analysis
Authors
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Supports perioperative levosimendan to reduce AKI risk in cardiac surgery; strengthens Level 1 evidence via meta-analysis.
Meta-Analysis (n=529)
Does perioperative levosimendan reduce the incidence of acute kidney injury in adult patients undergoing cardiac surgery?
Perioperative use of levosimendan may offer renal protection and reduce the incidence of acute kidney injury in adults undergoing cardiac surgery.
Niu et al. (2013) conducted a meta-analysis in Acute kidney injury after cardiac surgery (n=529). Levosimendan vs. Placebo or any other control was evaluated on Acute kidney injury (AKI). In a meta-analysis of 529 patients, perioperative levosimendan therapy decreased the postoperative incidence of acute kidney injury compared to control in adults undergoing cardiac surgery.
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