Key result
Average left ventricular mid-diastolic wall thickness measured by CT angiography was 7.24 mm, with significant differences between men (7.90 mm) and women (6.47 mm; P<0.001).
Why the study?
Normal reference values for left ventricular mid-diastolic wall thickness measured by CT angiography needed to be generated.
Observational (n=2,383)
This study establishes sex- and age-specific normal reference ranges for left ventricular mid-diastolic wall thickness on coronary CT angiography, potentially expanding its diagnostic utility for cardiomyopathies.
Purpose To generate normal reference values for left ventricular mid-diastolic wall thickness (LV-MDWT) measured by using CT angiography. Materials and Methods LV-MDWT was measured in 2383 consecutive patients, without structural heart disease, undergoing prospective electrocardiographically (ECG) triggered mid-diastolic coronary CT angiography. LV-MDWT was manually measured on automatically segmented short-axis images according to the American Heart Association’s 17-segment model. Commercially available automatic software was used to calculate the left ventricular (LV) mass. Results Among the 2383 patients, average LV-MDWT was 7.24 mm ± 1.86 (standard deviation [SD]), with the basal anteroseptal segment being the thickest wall (8.71 mm ± 2.19) and the apical inferior segment being the thinnest wall (5.9 mm ± 1.58; P < .001). Over all LV segments, the maximum upper limit, as defined as 2 SD above the mean, was 13.6 mm for men (LV1) and 11.2 mm for women. For men, only the basal anterior segment was above 13 mm. There was a significant difference in average LV-MDWT between women and men with 6.47 mm ± 1.07 and 7.90 mm ± 1.24, respectively (P < .001). Significant differences in LV-MDWT were found in the subgroups aged less than 65 years and greater than or equal to 65 years (P < .001). There was a strong correlation between LV-MDWT and LV mass (P < .001). Conclusion Normal sex- and age-specific reference ranges for LV-MDWT in prospective ECG-triggered mid-diastolic coronary CT angiography have been provided. These benchmarks may expand the diagnostic and prognostic roles of CT angiography, beyond its role in the identification of coronary artery disease.
No takes yet. Share an insight, caveat, or question.
Walpot et al. (2019) conducted an observational in Without structural heart disease (n=2,383). Prospective ECG-triggered mid-diastolic coronary CT angiography was evaluated on Average left ventricular mid-diastolic wall thickness (LV-MDWT). Average left ventricular mid-diastolic wall thickness measured by CT angiography was 7.24 mm, with significant differences between men (7.90 mm) and women (6.47 mm; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: