Key result
Real time 3D echocardiography revealed that patients with dilated cardiomyopathy had significantly higher regional volumes and dyssynchrony, and lower regional ejection fraction than controls (P<0.01).
Why the study?
Does real time three-dimensional echocardiography (RT-3DE) effectively evaluate left ventricular regional systolic function and dyssynchrony in patients with dilated cardiomyopathy compared to normal controls?
Observational (n=74)
Does real time three-dimensional echocardiography (RT-3DE) effectively evaluate left ventricular regional systolic function and dyssynchrony in patients with dilated cardiomyopathy compared to normal controls?
Real time three-dimensional echocardiography provides a feasible approach to quantify left ventricular regional systolic function and dyssynchrony in patients with dilated cardiomyopathy.
RT-3DE may aid regional LV assessment in DCM; leaves open need for prospective validation before clinical use.
PURPOSE: To evaluate left ventricular (LV) regional systolic function and dyssynchrony in patients with dilated cardiomyopathy (DCM) by real time three-dimensional echocardiography (RT-3DE). METHODS: The study population comprised 30 normal controls (NOR) and 44 patients with DCM. We divided the left ventricle into apical, middle, and basal regions. We calculated the LV regional end-diastolic volume ((R)EDV), regional end-systolic volume ((R)ESV), regional ejection fraction ((R)EF), and standard deviation in the time to minimal systolic volume in each level segment (Tmsv-SD) of the three regions by RT-3DE. RESULTS: Compared with NOR, the (R)EDV, (R)ESV, and Tmsv-SD of DCM were significantly higher, whereas the (R)EF was lower (P < 0.01). In DCM, the Tmsv-SD increased smoothly from base to apex, and the (R)EF gradually decreased from base to apex (P < 0. 05). Linear correlation was observed between the Tmsv-SD of the middle region and 3D-EF in DCM (r =-0. 6829, P < 0.01). CONCLUSION: RT-3DE provides a simple and feasible approach to quantify LV regional systolic function and dyssynchrony.
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Mu et al. (2010) conducted an observational in Dilated cardiomyopathy (n=74). Dilated cardiomyopathy vs. Normal controls was evaluated on Left ventricular regional end-diastolic volume, end-systolic volume, ejection fraction, and standard deviation in time to minimal systolic volume (p=<0.01). Real time 3D echocardiography revealed that patients with dilated cardiomyopathy had significantly higher regional volumes and dyssynchrony, and lower regional ejection fraction than controls (P<0.01).
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