Key result
Acute myocardial infarction was associated with significantly greater M1 macrophage infiltration (CD11c positivity) in culprit coronary plaques compared with stable angina (P=0.007).
Why the study?
Are M1 and M2 macrophage polarization states different in culprit coronary plaques of patients with acute myocardial infarction versus stable angina pectoris?
Observational (n=74)
Are M1 and M2 macrophage polarization states different in culprit coronary plaques of patients with acute myocardial infarction versus stable angina pectoris?
M1 macrophage infiltration is increased in culprit plaques of patients with acute myocardial infarction compared to stable angina, suggesting a role in plaque instability.
Answers are grounded in this paper and cite their sources.
No immediate change to plaque assessment or therapy; leaves open whether M1 modulation could stabilize culprit lesions.
We investigated the polarization states of macrophages in coronary atherectomy tissues retrieved from patients with acute myocardial infarction (AMI, n = 52) or stable angina pectoris (SAP, n = 22). The specimens were analyzed immunohistochemically using antibodies specific to CD11c (M1 marker), CD206 (M2 marker), and to markers of endothelial cells, macrophages, and smooth muscle cells. Baseline characteristics were similar in the 2 groups. The proportion of areas immunopositive for α smooth muscle actin was similar, but those positive for CD31 and CD68 were larger in the AMI group compared with the SAP group. In addition, AMI had significantly greater areas immunopositive for CD11c (P = .007) than did SAP, but CD206 (P = .102) positivity was not different in the 2 groups. In conclusion, M1 macrophage infiltration, not M2 macrophage infiltration, was increased in culprit plaques of patients with AMI. Macrophage heterogeneity may therefore be related to plaque instability.
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Lee et al. (2013) conducted an observational in Acute Myocardial Infarction or Stable Angina Pectoris (n=74). Acute Myocardial Infarction vs. Stable Angina Pectoris was evaluated on Areas immunopositive for CD11c (M1 marker) (p=0.007). Acute myocardial infarction was associated with significantly greater M1 macrophage infiltration (CD11c positivity) in culprit coronary plaques compared with stable angina (P=0.007).
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