Why the study?
The association of polarized macrophages in pericoronary perivascular adipose tissue with measurements of atherosclerosis components in humans had not been fully investigated.
Is macrophage polarization in perivascular adipose tissue associated with coronary atherosclerosis severity and plaque vulnerability?
Is macrophage polarization in perivascular adipose tissue associated with coronary atherosclerosis severity and plaque vulnerability?
Proinflammatory M1 macrophages in perivascular adipose tissue are associated with histological markers of coronary plaque progression and destabilization, including increased thrombosis risk.
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Perivascular M1/M2 imbalance may signal vulnerable plaques; hypothesis-generating and requires prospective validation before clinical use.
Farias‐Itao et al. (2022) studied this question.
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