Natural Killer (NK) cells represent a distinctive lineage of lymphocytes that aremorphologically large granular lymphocytes (LGL) and express CD 56 surface antigen. NK cell neoplasms are highly aggressive, rare and demonstrate an association with Epstein Barr virus (EBV). We report a case of a 68 year old white male who presented with fever and drenching night sweats of four weeks duration. His clinical status deteriorated despite aggressive supportive treatment; finally patient succumbed to multisystem organ failure (MSOF).
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