Background: Low-ionic strength solution (LISS) enhances antigen-antibody reaction thereby reducing two hours necessary for standard crossmatch test to ten minutes. However, the use LISS is becoming unpopular nowadays for unknown reason. Objectives: To perform ten-minutes low-ionic strength solution (LISS) antihuman globulin (AHG) crossmatch and compare the results to that of two-hour full antihuman globulin crossmatch. Methods: Ten minute LISS-AHG and two-hour full AHG crossmatch test were performed using standard techniques. Results: The pattern of compatibility and incompatibility reactions with the two techniques were comparable. Conclusions: Ten-minute LISS-AHG crossmatch was as effective and safe as two hour full AHG crossmatch.
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A 2006 study studied this question.
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