Key result
Combining Impella with VA-ECMO reduced short-term all-cause mortality (RR 0.86) compared to VA-ECMO alone in patients with cardiogenic shock.
Why the study?
Does left ventricular unloading with Impella during VA-ECMO reduce short-term mortality in patients with cardiogenic shock?
Does left ventricular unloading with Impella during VA-ECMO reduce short-term mortality in patients with cardiogenic shock?
Relative Risk: 0.86 (95% CI 0.76–0.96)
p-value: p=0.009
Combining Impella with VA-ECMO (ECMELLA) mitigates the detrimental increase in left ventricular afterload caused by VA-ECMO alone, potentially improving short-term survival in cardiogenic shock.
1Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland 2Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland 3Geneva Hemodynamic Research Group, 1206 Geneva, Switzerland 4Department of Cardio-thoracic Surgery Istituto Clinico Sant’Ambrogio, Gruppo Ospedaliero San Donato, Milan, and Chair of Cardiac Surgery, University of Milan, 20149 Milan, Italy *Correspondence: raphael.giraud@hcuge.ch (Raphaël Giraud) Academic Editor: Peter A. McCullough Submitted: 13 December 2021 Revised: 16 December 2021 Accepted: 17 December 2021 Published: 8 January 2022
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Giraud et al. (2022) conducted an editorial in Cardiogenic shock (n=972). Impella combined with VA-ECMO (ECMELLA) vs. VA-ECMO without Impella was evaluated on Short-term all-cause mortality (RR 0.86, 95% CI 0.76-0.96, p=0.009). Combining Impella with VA-ECMO reduced short-term all-cause mortality (RR 0.86) compared to VA-ECMO alone in patients with cardiogenic shock.
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