Why the study?
Does high porosity, low density PTFE improve patency and tissue reaction compared to dense PTFE in canine small vessel replacement?
Does high porosity, low density PTFE improve patency and tissue reaction compared to dense PTFE in canine small vessel replacement?
High porosity, low density PTFE conduits demonstrate superior patency and favorable tissue healing in a canine model of small vessel replacement.
Does not support clinical use of high-porosity PTFE; hypothesis-generating for human vascular graft trials.
Conduits of expanded, fibrillated polytetrafluoroethylene (PTFE [Gore-tex]) have been evaluated as small vessel prostheses in dogs during a 6-month period. A configuration of high porosity and low density, long fibril Gore-tex was found to yield the best patency in canine arteries (femoral and carotid) and veins (femoral) as compared with more dense, less porous PTFE with shorter fibrils. Host tissue reaction showed minimal inflammation, excellent infiltration, and formation of a smooth neointima, which suggested satisfactory acceptance of the prosthesis.
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Agustin Florian (1976) studied this question.
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