Collagen tubes with a polyester mesh endoskeleton were grown in sheep around silastic mandrils and were then tanned in alkaline glutaraldehyde. Tanned ovine collagen conduits and polytetrafluoroethylene conduits (Gore-Tex), each 10 cm long and 6 mm wide, were deployed in parallel as aorto-iliac bypass grafts in 10 dogs. The grafts remained patent for periods up to and exceeding 23 months. No grafts showed aneurysmal dilatation. All grafts formed a neointima lined with cells. In the Gore-Tex grafts there was fibrous tissue ingrowth through the wall which resulted in progressive and irregular luminal narrowing. This was not seen in the tanned ovine collagen grafts.
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Ketharanathan et al. (1981) studied this question.