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January 27, 2022International Journal of StrokeOpen Access

Endovascular treatment with versus without tirofiban for stroke patients with large vessel occlusion: The multicenter, randomized, placebo-controlled, double-blind RESCUE BT study protocol

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Why the study?

It remains unknown whether tirofiban improves clinical outcomes in patients with large vessel occlusion stroke undergoing endovascular treatment within 24 hours of symptom onset.

Does intravenous tirofiban improve disability level in large vessel occlusion stroke patients undergoing endovascular treatment?

Population

Up to 930 large vessel occlusion stroke patients undergoing endovascular treatment within 24 h of symptom onset

Comparison

Intravenous tirofiban vs placebo

Design

Investigator-initiated, randomized, placebo-controlled, double-blind, multicenter trial

Follow-up

90 days

Authors

ZQZhongming Qiu117th Hospital of People's Liberation ArmyFLFengli LiAnhui Medical UniversityHSHongfei SangArmy Medical University

Discussion

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Implication

Tirofiban adjunct in LVO stroke EVT remains unproven; RESCUE BT RCT will deliver first dedicated efficacy-safety data.

Structured PICO

Does intravenous tirofiban improve disability level in large vessel occlusion stroke patients undergoing endovascular treatment?

P
Population
Up to 930 patients with large vessel occlusion stroke who undergo endovascular treatment within 24 h of symptom onset across 50 centers in China.
I
Intervention
Intravenous tirofiban
C
Comparator
Placebo
O
Outcome
Disability level as measured by overall distribution of the 90-day modified Rankin Scale scoreshard clinical

This protocol describes the RESCUE BT trial, which will evaluate the efficacy and safety of intravenous tirofiban in patients with large vessel occlusion stroke undergoing endovascular treatment.

Cite This Study

Qiu et al. (2022) studied this question.

synapsesocial.com/papers/6a84919cde69cb059c7301aahttps://doi.org/10.1177/17474930211069510
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety of Tirofiban in Acute Ischemic Stroke2011 · 178 citations
  2. 2Comparison of Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes Treated with the Glycoprotein IIb/IIIa Inhibitor Tirofiban2001 · 2,117 citations
  3. 3A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke2014 · 6,712 citations
  4. 4Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke2015 · 4,937 citations
  5. 5Platelet Glycoprotein IIb/IIIa Receptors in Cardiovascular Medicine1995 · 762 citations