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August 27, 2009AJP Cell Physiology

The mechanical behavior of individual sarcomeres of myofibrils isolated from rabbit psoas muscle

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Population

Single myofibrils from rabbit psoas muscle

Design

Preclinical

Authors

IPIvan PavlovUniversité de MontréalRNRowan NovingerDRDilson E. RassierSimon Fraser University

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Implication

Novel single-sarcomere assays enable precise mechanics studies; extends basic research but leaves clinical translation open.

Structured PICO

P
Population
Single myofibrils from rabbit psoas muscle
I
Intervention
Mechanical isolation of sarcomeres using precalibrated glass microneedles
O
Outcome
Force produced during activation and sarcomere/half-sarcomere changes (tracking Z-lines and A-bands)surrogate

A novel technique for monitoring force and length in single isolated sarcomeres provides a reliable method to evaluate contractile mechanisms at the basic level of muscle organization.

Cite This Study

Pavlov et al. (2009) studied this question.

synapsesocial.com/papers/6a84975f4e8c7cff228d7f68https://doi.org/10.1152/ajpcell.00233.2009
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