Why the study?
The 2020 ESC guidelines recommend hs-cTn-based 0/1-hour and 0/2-hour algorithms over the 0/3-hour algorithm for suspected AMI triage, but their comparative diagnostic accuracies required systematic evaluation.
Do the ESC 0/1-hour and 0/2-hour algorithms improve diagnostic accuracy for index AMI compared to the 0/3-hour algorithm in adult patients presenting with suspected AMI?
Population
30 066 adult patients presenting with suspected AMI across 32 studies (20 cohorts)
Comparison
ESC 0/1-hour vs 0/2-hour vs 0/3-hour algorithms
Design
Systematic review and meta-analysis of prospective studies
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Supports faster AMI rule-out with 0/1-hour algorithm; confirms superiority of ESC high-sensitivity protocols over 0/3-hour testing.
Do the ESC 0/1-hour and 0/2-hour algorithms improve diagnostic accuracy for index AMI compared to the 0/3-hour algorithm in adult patients presenting with suspected AMI?
The ESC 0/1-hour and 0/2-hour algorithms provide higher sensitivity and negative predictive value for ruling out acute myocardial infarction compared to the 0/3-hour algorithm.
A 2021 study studied this question.
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