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The ATP-dependent breakdown of mitochondria-containing stroma proceeds via the ubiquitin-requiring pathway. The proteolysis is linked to a large ATP-cleaved consumption amounting to 1 ATP per peptide bond or more. Proteins of mitochondria-containing stroma are much better substrates of ATP-ubiquitin-dependent proteolysis than heat-denatured ones. Hemin suppresses both proteolysis and ATP hydrolysis.
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Rapoport et al. (1985) studied this question.
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