Why the study?
Does cerivastatin reduce Ang II-induced vascular injury and cardiac hypertrophy in a double transgenic rat model?
Does cerivastatin reduce Ang II-induced vascular injury and cardiac hypertrophy in a double transgenic rat model?
Statins may protect against Ang II-induced vascular injury and cardiac hypertrophy through cholesterol-independent mechanisms involving inhibition of intracellular signaling pathways.
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Suggests pleiotropic statin effects in Ang II cardiac injury; hypothesis-generating and requires clinical validation.
Dechend et al. (2002) studied this question.
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