July 31, 2001CirculationOpen Access

Amelioration of Angiotensin II–Induced Cardiac Injury by a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor

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Why the study?

Does cerivastatin reduce angiotensin II-induced cardiac injury in a transgenic rat model?

Structured PICO

Does cerivastatin reduce angiotensin II-induced cardiac injury in a transgenic rat model?

Population

Rats transgenic for human renin and angiotensinogen (dTGR)

Intervention

Cerivastatin 0.5 mg/kg by gavage chronically from weeks 4 to 7

Comparator

Control dTGR

Outcome

Cardiac injury (including mortality, blood pressure, cardiac hypertrophy, macrophage infiltration, and extracellular matrix deposition)surrogate

Cerivastatin ameliorates angiotensin II-induced cardiac injury, hypertension, and remodeling in a rat model independently of cholesterol reduction, highlighting the pleiotropic effects of statins.

Discussion

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Implication

Supports statin pleiotropy in angiotensin II-mediated cardiac injury; leaves open translation to human hypertension or heart failure.

Cite This Study

Dechend et al. (2001) studied this question.

synapsesocial.com/papers/6a71d9dece524a4339c52b48 https://doi.org/10.1161/hc3001.092039

Topics

Statin therapy Cardiovascular prevention

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Amelioration of Angiotensin II–Induced Cardiac Injury by a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor

Structured PICO

Discussion

Implication

Cite This Study

Topics

Amelioration of Angiotensin II–Induced Cardiac Injury by a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider