Key result
Rosuvastatin significantly improved ventricular ejection fraction, cardiac hypertrophy, and perivascular fibrosis, and decreased myocardial oxidative stress in Ren2 transgenic rats (P<0.05).
Why the study?
Does rosuvastatin reduce cardiac oxidative stress and remodeling in Ren2 transgenic rats?
Population
6- to 7-week-old Ren2 transgenic rats overexpressing the mouse renin gene with elevated cardiac levels of…
Comparison
Rosuvastatin 10 mg/kg/day for 3 weeks vs Vehicle for 3 weeks
Design
Preclinical
Follow-up
3 weeks
Authors
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Does not alter clinical statin use in HF; extends preclinical data on remodeling in Ang-II models but remains hypothesis-generating.
Does rosuvastatin reduce cardiac oxidative stress and remodeling in Ren2 transgenic rats?
p-value: p=<0.05
Rosuvastatin reduces cardiac oxidative stress and remodeling in an Ang-II-dependent transgenic rat model, independent of blood pressure lowering.
Habibi et al. (2007) studied Cardiac oxidative stress and remodeling. Rosuvastatin vs. Vehicle was evaluated on Left ventricular mass, wall thickness, ejection fraction, and cardiac remodeling (p=<0.05). Rosuvastatin significantly improved ventricular ejection fraction, cardiac hypertrophy, and perivascular fibrosis, and decreased myocardial oxidative stress in Ren2 transgenic rats (P<0.05).