Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry

Elevated lipoprotein(a) [Lp(a)] is an independent risk factor for coronary heart disease, ischemic stroke, and calcific aortic valve stenosis. Mediated by the LPA gene, elevated Lp(a) is the most common inherited dyslipidemia affecting ∼20% of individuals.1 Lp(a) levels ≥50 mg/dL (≈125 nmol/L) correspond to the 80th percentile and represent the threshold at which its impact on atherosclerotic cardiovascular disease (ASCVD) becomes clinically meaningful.2 Given its genetic underpinnings, levels of Lp(a) are relatively stable throughout an individual’s lifetime and likely contribute to an accumulating risk starting from a young age.3 Current American Heart Association/American College of Cardiology guidelines view a family history of premature ASCVD as...