Correlates and Heritability of Nonalcoholic Fatty Liver Disease in a Minority Cohort
Population
1,142 adults participating in the Insulin Resistance Atherosclerosis Study Family Study, mean age 49 years…
Design
Cohort
Authors
Discussion
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Member takes
Overview
Ethnic disparities in NAFLD prevalence warrant awareness; leaves open ancestry-specific genetic contributions to risk.
Structured PICO
P
Population
1,142 adults (795 Hispanic American and 347 African-American) participating in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study, mean age 49 years, 66% female.
O
Outcome
Risk factors and heritability of NAFLD (assessed by CT liver-spleen density ratio)surrogate
NAFLD is more prevalent in Hispanic Americans than African Americans, with both shared and distinct correlates, and is modestly heritable in both groups.
Cite This Study
Wagenknecht et al. (2009) studied this question.