Why the study?
Does RR variation during beta-adrenergic blockade detect diminished cardiac parasympathetic activity in diabetic subjects compared to normal subjects?
Population
44 fasting supine subjects, comprising 22 diabetic subjects and 22 age-comparable normal subjects.
Comparison
Measurement of heart rate and RR variation… vs Age-comparable normal subjects.
Design
Cross-sectional
Authors
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Supports early parasympathetic assessment in diabetes; hypothesis-generating and requires prospective validation before practice change.
Does RR variation during beta-adrenergic blockade detect diminished cardiac parasympathetic activity in diabetic subjects compared to normal subjects?
Supine RR variation during deep breathing and beta-adrenergic blockade is a sensitive and reproducible method to detect early diminished cardiac parasympathetic activity in diabetic patients.
Cook et al. (1982) studied this question.
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