Why the study?
Does beat-to-beat R-R variation differ between healthy individuals and patients with diabetic polyneuropathy or autonomic failure?
Population
Healthy volunteers and patients with diabetic polyneuropathy (with and without symptoms of autonomic failure)
Comparison
Measurement of beat-to-beat heart rate variation… vs Age-matched healthy controls
Design
Case-control
Authors
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Supports R-R variation testing for autonomic dysfunction in diabetic polyneuropathy; leaves open prospective validation beyond case-control data.
Does beat-to-beat R-R variation differ between healthy individuals and patients with diabetic polyneuropathy or autonomic failure?
R-R interval variation during breathing and tilting is a useful test for detecting autonomic dysfunction, such as in diabetic polyneuropathy.
Persson et al. (1983) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: