January 1, 1992Nucleic Acids ResearchOpen Access

Solid-phase synthesis of an RNA nucleopeptide fragment from the nucleoprotein of poliovirus

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Population

RNA-nucleopeptide H-Ala-Tyr[5'-pUUAAAAC-3']-NH2 from the nucleoprotein of poliovirus

Design

Preclinical

Authors

Discussion

No immediate clinical implications for antiviral therapy; leaves open conformational insights for nucleopeptide research.

Population

RNA-nucleopeptide H-Ala-Tyr[5'-pUUAAAAC-3']-NH2 from the nucleoprotein of poliovirus

Intervention

Solid-phase phosphite triester approach using N-SiOMB/O-TBDMS-protected nucleosides

Outcome

Conformational behaviour of the RNA moiety in the nucleopeptide

The peptidyl unit significantly affects the conformational behavior of the RNA moiety in the synthesized poliovirus nucleopeptide fragment.

Dreef-Tromp et al. (1992) studied this question.

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