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June 1, 2004The Journal of PhysiologyOpen Access

Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels

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Population

Human ether-à-go-go related gene-encoded K channels expressed in Chinese hamster ovary cells

Design

Preclinical

Authors

FMFranklin M. MullinsStanford UniversitySSSvetlana Z. StepanovicUniversity of KragujevacNGNiloufar B. GillaniMiddle Tennessee State University

Discussion

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Implication

Links Na+ to HERG inactivation in vitro; leaves open effects on human repolarization or arrhythmia risk.

Structured PICO

P
Population
Human ether-à-go-go related gene (HERG)-encoded K(+) channels expressed in Chinese hamster ovary (CHO-K1) cells
I
Intervention
Varying concentrations of extracellular Na(+) and K(+)
O
Outcome
HERG current inhibition and recovery from inactivationsurrogate

This basic science study reveals a direct link between extracellular sodium inhibition and inactivation gating in HERG channels, requiring a two-site kinetic model to explain the interaction.

Cite This Study

Mullins et al. (2004) studied this question.

synapsesocial.com/papers/6a84fc4fcba32192a79ea63ehttps://doi.org/10.1113/jphysiol.2004.065193
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons1971 · 937 citations
  2. 2A family of potassium channel genes related to eag in Drosophila and mammals.1994 · 991 citations
  3. 3Time, voltage and ionic concentration dependence of rectification of h‐erg expressed in Xenopus oocytes1996 · 77 citations
  4. 4Fast and Slow Voltage Sensor Movements in HERG Potassium Channels2002 · 118 citations
  5. 5A plethora of mechanisms in the HERG-related long QT syndrome Genetics meets electrophysiology1999 · 59 citations