Key result
External Ca2+ and Mg2+ block the HERG channel in a voltage- and time-dependent manner, with block facilitated by hyperpolarization.
Population
Xenopus oocytes expressing the human eag-related gene (HERG)
Comparison
External Ca2+ and Mg2+ vs Varying concentrations of external Ca2+, Mg2+…
Design
Preclinical
Authors
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Refines HERG gating models by attributing voltage dependence partly to cation block; extends in vitro biophysics but leaves in vivo relevance open.
External Ca2+ and Mg2+ block HERG channels in a voltage- and time-dependent manner, which contributes to the voltage dependence previously attributed to the activation gate.
Ho et al. (1998) studied this question. External Ca2+ and Mg2+ was evaluated on HERG current (IHERG) amplitude and kinetics. External Ca2+ and Mg2+ block the HERG channel in a voltage- and time-dependent manner, with block facilitated by hyperpolarization.
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