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May 1, 1987Journal of Clinical PathologyOpen Access

Control of oral anticoagulant treatment by chromogenic prothrombin assay.

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Why the study?

Does an automated chromogenic assay of prothrombin (CPA) satisfactorily monitor doses in patients on long term oral anticoagulant treatment?

Population

50 patients on long term oral anticoagulant treatment

Design

Cohort

Follow-up

six months

Authors

JOJ. R. O’DonnellIWIsobel D. WalkerCross-Cutting CardiologyJDJ.F. DavidsonUniversity of Cambridge

Discussion

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Implication

Supports feasibility of automated chromogenic assay in small cohort; leaves open need for randomized validation versus conventional monitoring.

Structured PICO

Does an automated chromogenic assay of prothrombin (CPA) satisfactorily monitor doses in patients on long term oral anticoagulant treatment?

P
Population
50 patients on long term oral anticoagulant treatment
I
Intervention
Monitoring by automated chromogenic assay of prothrombin (CPA)
O
Outcome
Feasibility and satisfaction of monitoring oral anticoagulant dosessurrogate

An automated chromogenic assay of prothrombin provides a satisfactory and potentially safer alternative to conventional tests for monitoring oral anticoagulant therapy.

Cite This Study

O’Donnell et al. (1987) studied this question.

synapsesocial.com/papers/6a8500bd040a6e09f1f117dfhttps://doi.org/10.1136/jcp.40.5.500

Topics

Anticoagulation in AF
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Questions and Answers on Prothrombin Time Standardisation in Oral Anticoagulant Control1985 · 86 citations
  2. 2The British System for Anticoagulant Control1975 · 12 citations
  3. 3Turnover of Prothrombin, Factor VII and Factor IX in a Patient with Hemophilia A1961 · 23 citations