Why the study?
Does native prothrombin determination improve monitoring oral anticoagulant therapy compared to prothrombin time determination?
Does native prothrombin determination improve monitoring oral anticoagulant therapy compared to prothrombin time determination?
Native prothrombin is proposed as an alternative to prothrombin time for monitoring oral anticoagulant therapy.
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Caution against routine adoption for OAC monitoring; leaves open validation in prospective trials before any practice change.
Article Native prothrombin as an alternative to prothrombin time determination for monitoring oral anticoagulant therapy was published on February 1, 2009 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 47, issue 2).
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Albrecht Pfäfflin (2009) studied this question.
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