Population
Patients receiving oral anticoagulant therapy
Design
Review
Authors
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May explain excess bleeding risk with oral anticoagulants in North America; leaves open whether modern PT standardization has resolved regional differences.
Historical differences in PT reagent sensitivity have led to higher oral anticoagulant dosing and consequently a higher risk of bleeding in North America compared to the United Kingdom.
Hirsh et al. (1986) studied this question.
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