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Free fat cells prepared from epididymal fat of hypophysectomized rats by digestion with collagenase failed to exhibit increased glucose oxidation when exposed to insulin or growth hormone. Segments of epididymal fat from the same hypophysectomized rats responded normally to these hormones. When obtained from normal rats, both segments of epididymal fat and free adipocytes also exhibited normal sensitivity to insulin. Hormonal responsiveness of adipose cells of hypophysectomized animals was not restored by shortening the digestion period, addition of trypsin or phospholipase inhibitors or pretreatment of the donor animals with cortisone, triiodothyronine, or growth hormone.
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Eastman et al. (1971) studied this question.
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